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Invitrogen
GLP-1 Monoclonal Antibody (10), Biotin
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
ABS 033-10B-005
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
10
抗原
Synthetic GLP-1(7-17).
偶联物
Biotin
Biotin
Biotin
形式
Liquid
浓度
1.04 mg/mL
规格
156 µg
纯化类型
purified
保存液
PBS, pH 7.4
内含物
15mM sodium azide
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
ABS 033-10B-005 detects GLP1 from human samples. ABS 033-10B-005 is specific towards the free N-terminus of GLP-1(7-37) and GLP-1(7-36)amide.
ABS 033-10B-005 has been successfully used in ELISA procedures.
NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL
靶标信息
GCG is also known as GLP1, or Glucagon. Glucagon is a 29-amino acid pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis.It is mapped to 2q36-2q37. GLP1, also known as 7-37 for the codons of the preproglucagon molecule which encode it, renders pancreatic beta-cells 'glucose-competent' and may be useful in the treatment of noninsulin-dependent diabetes mellitus. Also, GLP1 is a potent insulin secretagogue.It plays a major role in the enteroinsular axis, accounting, for example, for the finding that plasma insulin levels accompanying oral intake of glucose are greater than those observed when glucose is given intravenously.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: glicentin-related polypeptide; GLP1/2; Glucagon like peptide 1; glucagon-like peptide 1; glucagon-like peptide 2; incretin; MGC138331; OXY; preproglucagon; Pro-glucagon
基因别名: GCG; GLP-1; GLP1; GLP2; GRPP
Entrez Gene ID: (Human) 2641
cellular glucose homeostasis
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
feeding behavior
response to activity
positive regulation of insulin secretion
positive regulation of insulin secretion involved in cellular response to glucose stimulus
glucose homeostasis
negative regulation of apoptotic process
positive regulation of gluconeogenesis
regulation of insulin secretion
positive regulation of ERK1 and ERK2 cascade
cellular response to glucagon stimulus
positive regulation of calcium ion import
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